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Publications 2016 Goto Top   |  Pubs 2016  |  2015  |   2014  |  2013  |  2012  |  older  |   Documentation

The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening
by Fudan Zhenga, Alan P. Robertsonb, Melanie Abongwab, Edward W. Yua, c, Richard J. Martin
Volume 6, Issue 1, April 2016, Pages 60–73
doi:10.1016/j.ijpddr.2016.02.001
Bioresorbable silicon electronic sensors for the brain
by Seung-Kyun Kang, Rory K. J. Murphy, Suk-Won Hwang, Seung Min Lee, Daniel V. Harburg, Neil A. Krueger, Jiho Shin, Paul Gamble, Huanyu Cheng, Sooyoun Yu, Zhuangjian Liu, Jordan G. McCall, Manu Stephen, Hanze Ying, Jeonghyun Kim, Gayoung Park, R. Chad Webb, Chi Hwan Lee, Sangjin Chung, Dae Seung Wie, Amit D. Gujar, Bharat Vemulapalli, Albert H. Kim, Kyung-Mi Lee, Jianjun Cheng
Nature 530, 71–76 (04 February 2016) doi:10.1038/nature16492 Received 14 March 2015 Accepted 18 November 2015 Published online 18 January 2016

Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms
by Melanie Abongwa, Samuel K. Buxton, Alan P. Robertson, and Richard J. Martin
PLoS One. 2016; 11(1): e0146854.
Published online 2016 Jan 11. doi: 10.1371/journal.pone.0146854

Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel
by Stephanie A. Heusser1, Özge Yoluk, Göran Klement, Erika A. Riederer, Erik Lindahl1, andRebecca J. Howard
DOI: 10.1111/jnc.13644

Experimentally optimized threading structures of the proton‐coupled folate transporter
by Swapneeta S. Date, Cheng‐Yen Charles Chen,Yidong Chen, and Michaela Jansencorresponding author
FEBS Open Bio. 2016 Mar; 6(3): 216–230. Published online 2016 Feb 22. doi: 10.1002/2211-5463.12041

Publications 2015 Goto Top   |  Pubs 2016  |  2015  |   2014  |  2013  |  2012  |  older  |   Documentation

The Xenopus tropicalis orthologue of TRPV3 is heat sensitive
by Beiying Liu and Feng Qin
Published October 12, 2015 // JGP vol. 146 no. 5 411-421
The Rockefeller University Press, doi: 10.1085/jgp.201511454 © 2015 Liu and Qin

A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm
by Sylvia Fechner,Luis Alvarez,Wolfgang Bönigk,Astrid Müller,Thomas K Berger,Rene Pascal,Christian Trötschel,Ansgar Poetsch,Gabriel Stölting,Kellee R Siegfried,Elisabeth Kremmer,Reinhard Seifert,U Benjamin Kaupp
DOI: 10.7554/eLife.07624

Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology
by Ghanim Ullah, Angelo Demuro, Ian Parker, and John E. Pearson
PLoS One. 2015; 10(9): e0137357.Published online 2015 September 8. doi: 10.1371/journal.pone.0137357

NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes
by Veronika Matschke, Carsten Theiss, Michael Hollmann, Eric Schulze-Bahr, Florian Lang, Guiscard Seebohm and Nathalie Strutz-Seebohm
Front. Cell. Neurosci., 06 October 2015 | http://dx.doi.org/10.3389/fncel.2015.00387

Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology
by Ghanim Ullah , Angelo Demuro, Ian Parker, John E. Pearson
Published: September 8, 2015 http://dx.doi.org/10.1371/journal.pone.0137357

Varenicline Interactions at the 5‑HT3 Receptor Ligand Binding Site are Revealed by 5‑HTBP
by Kerry L. Price, † Reidun K. Lillestol, † Chris Ulens, ‡ and Sarah C.R. Lummis †
ACS Chem. Neurosci., 2015, 6 (7), pp 1151–1157DOI: 10.1021/cn500369h Publication Date (Web): February 03, 2015

Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones
by Doreen Braun and Ulrich Schweizer
DOI: http://dx.doi.org/10.1210/en.2015-1393Received: May 04, 2015
Accepted: September 09, 2015
First Published Online: September 14, 2015

Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors
by Paul A. Chrisman, Julie I. Podair, Emily M. Jobe, and Mark M. Levandoski
Neuropharmacology. Author manuscript; available in PMC 2015 April 1., Published in final edited form as:Neuropharmacology. 2014 April; 79: 420–431., Published online 2013 December 25. doi: 10.1016/j.neuropharm.2013.12.017

Solid phase synthesis, NMR structure determination of α-KTx3.8, its in silico docking to Kv1.x potassium channels, and electrophysiological analysis provide insights into toxin-channel selectivity
by Bastian Kohl, Ina Rothenberg, Syed Abid Ali,Mehtab Alam, Guiscard Seebohm, Hubert Kalbacher
Toxicon (Impact Factor: 2.58). 05/2015; 101. DOI: 10.1016/j.toxicon.2015.04.018 Source: PubMed

Die Wirkung von Nikotin auf trigeminal exprimierte Ionenkanäle
by Benjamin Sven Philip Schreiner
Lehrstuhl für Zellphysiologie Prof. Dr. Dr. Dr. Hanns Hatt

Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3′-Diiodothyronine Across the Plasma Membrane
by Kinne A., Wittner M., Wirth E.K., Hinz K.M., Schülein R., Köhrle J., Krause G.
Eur Thyroid J
(DOI:10.1159/000381542)

Homodimeric anoctamin-1, but not homodimeric anoctamin-6, is activated by calcium increases mediated by the P2Y1 and P2X7 receptors
by Michaela Stolz, Manuela Klapperstück, Thomas Kendzierski, Silvia Detro-dassen, Anna Panning, Günther Schmalzing, Fritz Markwardt
Pflügers Archiv - European Journal of Physiology January 2015 Date: 17 Jan 2015

Varenicline Interactions at the 5‑HT3 Receptor Ligand Binding Site are Revealed by 5‑HTBP
by Kerry L. Price, Reidun K. Lillestol, Chris Ulens, and Sarah C.R. Lummis
Methods in Enzymology

1-Octen-3-ol – the attractant that repels
by Pingxi Xu, Fen Zhu, Garrison K. Buss, Walter S. Leal
Methods in Enzymology

Membrane Proteins – Production and Functional Characterization
by Arun K. Shukla
18 Jun 2015, 4:156 (doi: 10.12688/f1000research.6646.1)

MANIPULATIONS OF EXTRACELLULAR LOOP 2 IN a1 GLYR ULTRA-SENSITIVE ETHANOL RECEPTORS (USERS) ENHANCE RECEPTOR SENSITIVITY TO ISOFLURANE, ETHANOL, AND LIDOCAINE, BUT NOT PROPOFOL
by A. NAITO, K. H. MUCHHALA, J. TRANG, L. ASATRYAN, J. R. TRUDELL, G. E. HOMANICS, R. L. ALKANA AND D. L. DAVIES
Neuroscience 297 (2015) 68–77

RNS60, a charge‐stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production
by Soonwook Choi , Eunah Yu , Duk‐Soo Kim , Mutsuyuki Sugimori , Rodolfo R. Llinás
Physiological Reports Published 5 March 2015 Vol. 3 no. e12261 DOI: 10.14814/phy2.12261

Publications 2014 Goto Top   |  Pubs 2016  |  2015  |   2014  |  2013  |  2012  |  older  |   Documentation

Homodimeric anoctamin-1, but not homodimeric anoctamin-6, is activated by calcium increases mediated by the P2Y1 and P2X7 receptors
by Michaela Stolz & Manuela Klapperstück & Thomas Kendzierski & Silvia Detro-dassen & Anna Panning & Günther Schmalzing & Fritz Markwardt
Received: 22 July 2014 /Revised: 23 December 2014 /Accepted: 6 January 2015

Regulation von TRPM3 durch α2-Adrenorezeptoren in pankreatischen β-Zellen
by Mohr, Florian
Philipps-Universität Marburg 2014-10-21Medizin

Mosquito odorant receptor for DEET and methyl jasmonate
by Pingxi Xu, Young-Moo Choo, Alyssa De La Rosa and Walter S. Leal
Edited by Jerrold Meinwald, Cornell University, Ithaca, NY, and approved October 3, 2014 (received for review September 8, 2014)

Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors
by Bettina U. Wilke, Moritz Lindner, Lea Greifenberg, Alexandra Albus, Yannick Kronimus, Moritz Bünemann, Michael G. Leitner & Dominik Oliver
Nature Communications5,Article number:5540, doi:10.1038/ncomms6540,Received 19 May 2014 Accepted 09 October 2014 Published 25 November 2014

Effects on Channel Properties and Induction of Cell Death Induced by C-terminal Truncations of Pannexin1 Depend on Domain Length.
by Engelhardt K, Schmidt M, Tenbusch M, Dermietzel R.
Department of Neuroanatomy and Molecular Brain Research, Ruhr-University Bochum, 44780, Bochum, Germany.
J Membr Biol. 2015 Jan 8. [Epub ahead of print]

Characterization of the Ca2+-Gated and Voltage-Dependent K+-Channel Slo-1 of Nematodes and Its Interaction with Emodepside
by Daniel Kulke, Georg von Samson-Himmelstjerna, Sandra M. Miltsch, Adrian J. Wolstenholme, Aaron R. Jex, Robin B. Gasser, Cristina Ballesteros, Timothy G. Geary, Jennifer Keiser, Simon Townson, Achim Harder, Jürgen Krücken mail
Published: December 18, 2014
DOI: 10.1371/journal.pntd.0003401

Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels
by Rene Raphemot, Matthew F. Rouhier, Daniel R. Swale, Emily Days, C. David Weaver, Kimberly M. Lovell, Leah C. Konkel, Darren W. Engers, Sean F. Bollinger, Corey Hopkins, Peter M. Piermarini, Jerod S. Denton
Received June 9, 2014; Accepted September 16, 2014; Published November 6, 2014

Characterization of a Prawn OA/TA Receptor in Xenopus Oocytes Suggests Functional Selectivity between Octopamine and Tyramine
by Sami H. Jezzini, Dalynés Reyes-Colón, María A. Sosa
Published: October 28, 2014
DOI: 10.1371/journal.pone.0111314

Effect of Cytosolic pH on Inward Currents Reveals Structural Characteristics of the Proton Transport Cycle in the Influenza A Protein M2 in Cell-Free Membrane Patches of Xenopus oocytes
by Mattia L. DiFrancesco, Ulf-Peter Hansen, Gerhard Thiel, Anna Moroni, Indra Schroeder
Published: September 11, 2014
DOI: 10.1371/journal.pone.0107406

Crystal structures of free and antagonist-bound states of human ​α9 nicotinic receptor extracellular domain
by Marios Zouridakis, Petros Giastas, Eleftherios Zarkadas, Dafni Chroni-Tzartou, Piotr Bregestovski & Socrates J Tzartos
Nature Structural & Molecular Biology 21, 976–980 (2014) doi:10.1038/nsmb.2900
Received 12 October 2013 Accepted 09 September 2014 Published online 05 October 2014

Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin
by Laura F. Eghorna, Kirsten Hoestgaard-Jensena, Kenneth T. Kongstada, Tina Baya, David Higginsb, Bente Frølunda, Petrine Wellendorpha,
Volume 740, 5 October 2014, Pages 570–577
doi:10.1016/j.ejphar.2014.06.028

Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives
by Liang Hong, Iris H. Kim, and Francesco Tombola1
Edited by Ramon Latorre, Centro Interdisciplinario de Neurociencias, Universidad de Valparaíso, Valparaíso, Chile, and approved May 1, 2014 (received for review December 23, 2013)

Evidence for Functional Diversity between the Voltage-Gated Proton Channel Hv1 and Its Closest Related Protein HVRP1
by Iris H. Kim, Peter Hevezi, Csaba Varga, Medha M. Pathak, Liang Hong, Dennis Ta, Chau T. Tran, Albert Zlotnik, Ivan Soltesz, Francesco Tombola
Published: August 28, 2014
DOI: 10.1371/journal.pone.0105926

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters
by Zachary Lee Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, Seok-Yong Lee
DOI: http://dx.doi.org/10.7554/eLife.03604
Published July 31, 2014 Cite as eLife 2014;3:e03604

Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimers disease and frontotemporal lobar degeneration
by Patrick Oeckl , Petra Steinacker , Christine A.F. von Arnim , Sarah Straub , Magdalena Nagl , Emily Feneberg , Jochen H. Weishaupt , Albert C. Ludolph , and Markus Otto
J. Proteome Res., Just Accepted Manuscript, DOI: 10.1021/pr5006058
Publication Date (Web): August 5, 2014

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters
by Zachary Lee Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, Seok-Yong Lee
DOI: http://dx.doi.org/10.7554/eLife.03604
Cite as: eLife 2014;10.7554/eLife.03604, Published: 31 July 2014

The novel a7ß2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: Biochemical and pharmacological characterisation
by Milena Moretti, Michele Zoli, Andrew A George, Ronald J Lukas, Francesco Pistillo, Uve Maskos, Paul Whiteaker, and Cecilia Gotti
Molecular Pharmacology Fast Forward.
Published on July 8, 2014 as doi:10.1124/mol.114.093377

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
by Freja H. Hansen, Tina Skjørringe, Saiqa Yasmeen, Natascha V. Arends, Michelle A. Sahai, Kevin Erreger, Thorvald F. Andreassen, Marion Holy, Peter J. Hamilton, Viruna Neergheen, Merete Karlsborg, Amy H. Newman, Simon Pope, Simon JR. Heales, Lars Friberg, Ian Law, Lars H. Pinborg, Harald H. Sitte, Claus Loland, Lei Shi, Harel Weinstein, Aurelio Galli, Lena E. Hjermind, Lisbeth B. Møller and Ulrik Gether
Copyright © 2014, The American Society for Clinical Investigation.
J Clin Invest. doi:10.1172/JCI73778.

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics
by Alicia Lundby, Elizabeth J Rossin, Annette B Steffensen, Moshe Rav Acha, Christopher Newton-Cheh, Arne Pfeufer, Stacey N Lynch, The QT Interval International GWAS Consortium (QT-IGC), Søren-Peter Olesen, Søren Brunak, Patrick T Ellinor, J Wouter Jukema, Stella Trompet, Ian Ford, Peter W Macfarlane, Bouwe P Krijthe, Albert Hofman, André G Uitterlinden, Bruno H Stricker, Hendrik M Nathoe, Wilko Spiering, Mark J Daly, Folkert W Asselbergs, Pim van der Harst, David J Milan et al.
Nature Methods (2014) doi:10.1038/nmeth.2997
Received 14 December 2013 Accepted 16 May 2014 Published online 22 June 2014

Pharmacological Validation of an Inward-Rectifier Potassium (Kir) Channel as an Insecticide Target in the Yellow Fever Mosquito Aedes aegypti
by Matthew F. Rouhier, Rene Raphemot, Jerod S. Denton, Peter M. Piermarini
Published: June 24, 2014
DOI: 10.1371/journal.pone.0100700

KCNQ1, KCNE2, and Na+-Coupled Solute Transporters Form Reciprocally Regulating Complexes That Affect Neuronal Excitability
by Geoffrey W. Abbott, Kwok-Keung Tai, Daniel L. Neverisky, Alex Hansler, Zhaoyang Hu, Torsten K. Roepke, Daniel J. Lerner, Qiuying Chen, Li Liu, Bojana Zupan, Miklos Toth, Robin Haynes, Xiaoping Huang, Didem Demirbas, Roberto Buccafusca, Steven S. Gross, Vikram A. Kanda, and Gerard T. Berry
Sci. Signal., 4 March 2014
Vol. 7, Issue 315, p. ra22 [DOI: 10.1126/scisignal.2005025]

Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy.
by Orhan G, Bock M, Schepers D, Ilina EI, Reichel SN, Löffler H, Jezutkovic N, Weckhuysen S, Mandelstam S, Suls A, Danker T, Guenther E, Scheffer IE, De Jonghe P, Lerche H, Maljevic S.
Ann Neurol. 2014 Mar;
75(3):382-94. doi: 10.1002/ana.24080. Epub 2014 M

Investigation of Acetylcholine Receptor Diversity in a Nematode Parasite Leads to Characterization of Tribendimidine- and Derquantel-Sensitive nAChRs
by Samuel K. Buxton equal contributor, Claude L. Charvet equal contributor, Cedric Neveu, Jacques Cabaret, Jacques Cortet, Nicolas Peineau, Melanie Abongwa, Elise Courtot, Alan P. Robertson, Richard J. Martin
Published: January 30, 2014
DOI: 10.1371/journal.ppat.1003870

 
Publications 2013 Goto Top   |  Pubs 2016  |  2015  |   2014  |  2013  |  2012  |  older  |   Documentation

Beta-Amyloid Inhibition of Alpha 7 Nicotinic Acetylcholine Receptors and Factors That Potentially Influence the Aβ/nAChR Interaction
by Christopher L. Jacobsen
Brigham Young University - Provo

Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain
by A Mingorance-Le Meur, P Ghisdal, B Mullier, P De Ron, P Downey, C Van Der Perren, V Declercq, S Cornelis, M Famelart, J Van Asperen, E Jnoff, and J P Courade
Br J Pharmacol. Nov 2013; 170(5): 1053–1063. Published online Oct 15, 2013. doi: 10.1111/bph.12343

Protein Structure and Folding: Crystal Structure and Pharmacological Characterization of a Novel NMDA Receptor Antagonist at the GluN1 Glycine Binding Site
by Trine Kvist, Thomas Bielefeldt Steffensen, Jeremy R. Greenwood, Fatemeh Mehrzad Tabrizi, Kasper B. Hansen, Michael Gajhede, Darryl S. Pickering, Stephen F. Traynelis, Jette Sandholm Kastrup and Hans Bräuner-Osborne
J. Biol. Chem. published online September 26, 2013
Access the most updated version of this article at doi: 10.1074/jbc.M113.480210

The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod γ-aminobutyric acid- and l-glutamate-gated chloride channels and insecticidal/acaricidal activity.
by Gassel M, Wolf C, Noack S, Williams H, Ilg T.
Insect Biochem Mol Biol. 2013 Dec 21.
pii: S0965-1748(13)00210-5. doi: 10.1016/j.ibmb.2013.11.009. [Epub ahead of print]

Functional Modulation of the Glutamate Transporter Variant GLT1b by the PDZ Domain Protein PICK1
by Rikke Sogaard, Lars Borre, Thomas H., Braunstein, Kenneth L. Madsen and Nanna, MacAulay
J. Biol. Chem. 2013, 288:20195-20207.
doi: 10.1074/jbc.M113.471128 originally published online May 22, 2013

Probing Insect Odorant Receptors with their Cognate Ligands: Insights into Structural Features.
by Pingxi Xu, Walter S Leal
Honorary Maeda-Duffey Laboratory, University of California, Davis, CA 95616 USA.
Biochemical and Biophysical Research Communications (Impact Factor: 2.41). 05/2013; DOI:10.1016/j.bbrc.2013.05.015

Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms
by Walter S. Leal, Young-Moo Choo, Pingxi Xu, Cherre S. B. da Silva, and Carlos Ueira-Vieira
Department of Molecular and Cellular Biology, University of California, Davis, CA 95616
Edited by Jerrold Meinwald, Cornell University, Ithaca, NY, and approved October 8, 2013 (received for review August 26, 2013)

A PI3K-SGK1 pathway promotes Kv7.1 surface expression by inhibiting Nedd4-2
by Martin Nybo Andersen, Katarzyna Krzystanek, Frederic Petersen, Sofia Hammami Bomholtz, Søren-Peter Olesen, Hugues Abriel, Thomas Jespersen and Hanne Borger Rasmussen
JBC Papers in Press. Published on November 8, 2013 as Manuscript M113.525931

The unique α4(+)/(-)α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology vs. the (α4)2(β2)3 subtype.
by J. Brek Eaton†, Linda M. Lucero†, Harrison Stratton, Yongchang Chang, John F. Cooper, Jon. M. Lindstrom, Ronald J. Lukas, and Paul Whiteaker
JPET Fast Forward. Published on November 4, 2013 as DOI:10.1124/jpet.113.208389
RNAi-based Demonstration of Direct Link between Specific Odorant Receptors andMosquito Oviposition Behavior
by Fen Zhu, Pingxi Xu, Rosângela M.R. Barbosa, Young-Moo Choo, Walter S. Leal
10.1016/j.ibmb.2013.07.008

Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors
by Trine Kvist, Jeremy R. Greenwood, Kasper B. Hansen, Stephen F. Traynelis, Hans Bräuner-Osborne
Dept. of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, DK-2100 Copenhagen, Denmark | Schrödinger, Inc., 120 West 45th St., New York, NY 10036, USA | Dept. of Pharmacology, Emory University School of Medicine, 5062 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
 2013 Published by Elsevier Ltd.

Mutations in SLC242 reveal hGLUT2 function in pancreatic beta cell development
by Aurelien Michau, Ghislaine Guillemain, Alexandra Grosfeld, Sandrine Vuillaumier-Barrot, Teddy Grand, Mathilde Keck, Sebastien L 'Hoste, Danielle Chateau, Patricia Serradas, Jacques Teulon, Pascale De Lonlay, Raphael Scharfman, Edith Brot-Laroche, Armelle Leturque and Maude Le Gall
J. Biol. Chem. published online August 28, 2013
First Published on August 28, 2013, doi: 10.1074/jbc.M113.469189 jbc.M113.469189.

Silent, Generic and Plant Kairomone Sensitive Odorant Receptors from the Southern House Mosquito
by Pingxi Xua, Young-Moo Chooa, Julien Pelletiera, Fernando R. Sujimotoa, David T. Hughesb, Fen Zhua, Elizabeth Atungulua, Anthony J. Cornelc, Charles W. Luetjeb, Walter S. Leala
Journal of Insect Physiology, 10.1016/j.jinsphys.2013.07.004

Nuclear Microinjection to Assess How Heterologously Expressed Proteins Impact Ca2+ Signals in Xenopus Oocytes
by Yaping Lin-Moshier and Jonathan S. Marchant
doi:10.1101/pdb.prot072785 Cold Spring Harb Protoc 2013.
© 2013 Cold Spring Harbor Laboratory Press

Analyse fonctionnelle de nouvelles mutations pathogènes ducanal chlorureCLC-KBimpliquées dans le syndrome de Bartter.
by Melle Mathilde KECK
L’UNIVERSITÉ PIERRE ET MARIE CURIE
Parasitic nematode ion channels: improving understanding of pharmacology and geneticcomposition
by Samuel Buxton
Iowa State University

Histidines in Potential Substrate Recognition Sites Affect Thyroid Hormone Transport by Monocarboxylate Transporter 8 (MCT8)
by Doreen Braun, Iva Lelios, Gerd Krause and Ulrich Schweizer
Published online before print April 16, 2013, doi: 10.1210/en.2012-2197
Endocrinology April 16, 2013 en.2012-2197

De-orphanization of Rhodnius prolixus Odorant Receptor
by Oliveira, D.S.; Xu, P.; Moreira,M.F.;Lea, W.S.;Melo,A.C.A.
DepartamentodeBioquímica,IQ,UFRJ,RJ,Brazil; University of California
XLII Annual Meeting of SBBq FozdoIguaçu,PR,Brazil,May18 th to21 st ,2013

Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl- D -aspartate receptors
byKevin K. Ogden and Stephen F. Traynelis
Department of Pharmacology, Emory University, Atlanta, GA 30322
Molecular Pharmacology Fast Forward. Published on March 1, 2013 as doi:10.1124/mol.113.085209

The Xenopus Oocyte: A Single-Cell Model for Studying Ca2+ Signaling
by Yaping Lin-Moshier and Jonathan S. Marchant
doi:10.1101/pdb.top066308 Cold Spring Harb Protoc 2013. © 2013 Cold Spring Harbor Laboratory Press

Regulation of AQP0 water permeability is enhanced by cooperativity.
by Németh-Cahalan KL, Clemens DM, Hall JE.
Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697.
J Gen Physiol. 2013 Mar;141(3):287-95. doi: 10.1085/jgp.201210884.

Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore
by Göran Klement, Lina Eisele, David Malinowsky, Andreas Nolting, Mats Svensson, Gitte Terp, Dirk Weigelt, and Michael Dabrowski
Biophys J. 2013 February 19; 104(4): 798–806.
doi: 10.1016/j.bpj.2013.01.008

Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels
by Robert Heler, Jessica K. Bell and Linda M. Boland
Channels (Austin). 2013 Jan 18;7(2). [Epub ahead of print] - Volume 7, Issue 2 March/April 2013

 
2012 Goto Top   |  Pubs 2016  |  2015  |   2014  |  2013  |  2012  |  older  |   Documentation

Cloning and functional characterization of inward-rectifying potassium (Kir) channels from Malpighian tubules of the mosquito Aedes aegypti
by Peter M. Piermarini, Matthew F. Rouhier, Matthew Schepel, Christin Kosse, Klaus W. Beyenbach
Insect Biochemistry and Molecular Biology
Article history:Received 27 July 2012, Received in revised form 12 September 2012, Accepted 30 September 2012

Color-tuned Channelrhodopsins for Multiwavelength Optogenetics
by Matthias Prigge, Franziska Schneider, Satoshi P. Tsunoda, Carrie Shilyansky, Jonas Wietek, Karl Deisseroth and Peter Hegemann
JBC Papers in Press. Published on July 27, 2012 as Manuscript M112.391185

Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
by David Strugatsky, Reginald McNulty, Keith Munson, Chiung-Kuang Chen, S. Michael Soltis, George Sachs & Hartmut Luecke
Nature (2012) | doi:10.1038/nature11684
Received 24 April 2012| Accepted 18 October 2012 | Published online 09 December 2012

Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages
by L Senerovic, S P Tsunoda, C Goosmann, V Brinkmann, A Zychlinsky, F Meissner and M Kolbe1
Cell Death Dis. 2012 September; 3(9): e384.Published online 2012 September 6. doi: 10.1038/cddis.2012.124

PIP2 hydrolysis stimulates electrogenic Na/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes.
by Ian M. Thornell, Jianping Wu, Xiaofen Liu1 and Mark O. Bevensee
Published online before print September 10, 2012, doi: 10.1113/jphysiol.2012.242479 The Journal of Physiology

Moth Sex Pheromone Receptors and Deceitful Parapheromones
by Pingxi Xu, Stephen F. Garczynski, Elizabeth Atungulu, Zainulabeuddin Syed, Young-Moo Choo, Diogo M. Vidal, Caio H. L. Zitelli, Walter S. Leal
Citation: Xu P, Garczynski SF, Atungulu E, Syed Z, Choo Y-M, et al. (2012) Moth Sex Pheromone Receptors and Deceitful Parapheromones. PLoS One. 2012;7(7):e41653. Epub 2012 Jul 20.

Purinergic signalling – a possible mechanism for KCNQ1 channel response to cell volume challenges
by S. Hammami, N. J. Willumsen, A.-K. Meinild, D. A. Klaerke, I. Novak1
Article first published online: 14 JUL 2012 - DOI: 10.1111/j.1748-1716.2012.02460.x - © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society

Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive acetylcholine receptors
by Claude L. Charvet, Alan P. Robertson, Jacques Cabaret, Richard J. Martin and Cédric Neveu
Invert Neurosci. Author manuscript; available in PMC 2012 June 1. Published in final edited form as: Invert Neurosci. 2012 June; 12(1): 43–51. Published online 2012 April 24. doi: 10.1007/s10158-012-0130-0

Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABAA receptor subtypes indicate a different binding mode for GABA at these receptors
Nasiara Karima, Petrine Wellendorphb, Nathan Absaloma, Line Haunstrup Bangc, Marianne Lerbech Jensenc, Maja Michelle Hansena, Ho Joon Leea, Graham A.R. Johnstond, Jane R. Hanrahana, Mary Chebiba
Biochemical Pharmacology - Volume 84, Issue 4, 15 August 2012, Pages 549–557 Received 4 February 2012. Accepted 21 May 2012. Available online 29 May 2012.

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation
SUPPLEMENTAL INFORMATION
by Morten S Olesen, Bo H Bentzen, Jonas B Nielsen, Annette B Steffensen, Jens-Peter David, Javad Jabbari, Henrik K Jensen, Stig Haunsø, Jesper H Svendsen and Nicole Schmitt - The Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark.
© 2012 Olesen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Physiological and Molecular Characterization of Connexin Hemichannels in Zebrafish Retinal Horizontal Cells
by Ziyi Sun, Michael L. Risner, Jorrit B. van Asselt, Dao-Qi Zhang, Maarten Kamermans and Douglas G. McMahon, Vanderbilt University
Submitted 9 December 2011. Revision received 6 February 2012. Accepted 21 February 2012.

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes
M Mezler,S Barghorn,H Schoemaker,G Gross,V Nimmrich
Article first published online: 10 FEB 2012 DOI: 10.1111/j.1476-5381.2011.01646.x
© 2011 Abbott GmbH & Co. KG. British Journal of Pharmacology © 10 FEB 2012 The British Pharmacological Society

Cotransport of water by Na+-K+-2Cl- cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2.
by Zeuthen T, Macaulay N., University of Copenhagen., J. Physiol. January 16, 2012, doi: 10.1113/jphysiol.2011.226316

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Mechanismus und anwendungsbezogene Optimierung von Channelrhodopsin-2
by Herr Dipl.-Biophys. André Berndt, geb. Kaschade

Extracellular potassium inhibits kv7.1 potassium channels by stabilizing an inactivated state.
by Anders Peter Larsen, Annette Buur Steffensen, Morten Grunnet, Søren-Peter Olesen Biophysical Journal (2011) Volume: 101, Issue: 4, Publisher: Biophysical Society, Pages: 818-827

ELEVATED AMMONIUM LEVELS: DIFFERENTIAL ACUTE EFFECTS ON THREE GLUTAMATE TRANSPORTER ISOFORMS
Søgaard R, Novak I, Macaulay N. - Am J Physiol Cell Physiol. 2011 Dec 7. [Epub ahead of print]Am J Physiol Cell Physiol. 2011 Dec 7. [Epub ahead of print]
University of Copenhagen. macaulay@sund.ku.dk

Single Cysteines in the Extracellular and Transmembrane Regions Modulate Pannexin 1 Channel Function
by Stefanie Bunse, Matthias Schmidt, Sarah Hoffmann, Kathrin Engelhardt, Georg Zoidl, Rolf Dermietzel
The Journal of Membrane Biology November 2011, Volume 244, Issue 1, pp 21-33
AMP-Activated Protein Kinase Downregulates Kv7.1 Cell Surface Expression
Martin N. Andersen, Katarzyna Krzystanek, Thomas Jespersen, Søren-Peter Olesen, Hanne B. Rasmussen
Article first published online: 26 OCT 2011 - DOI: 10.1111/j.1600-0854.2011.01295.x - ©2011 John Wiley & Sons A/S

NMR Separation of Intra- and Extracellular Compounds Based on Intermolecular Coherences
Verena Hoerr,†‡ Armin Purea,†§ and Cornelius Faber†‡*† Biophysical Journal, Volume 99, Issue 7, 2336-2343, 6 October 2010
Functional prokaryotic–eukaryotic chimera from the pentameric ligand-gated ion channel family
Guillaume Duret, Catherine Van Renterghem, Yun Weng, Marie Prevost, Gustavo Moraga-Cid, Christèle Huon, James M. Sonnerc, and Pierre-Jean Corringer
pnas.1104494108 PNAS July 5, 2011

Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor a1 and a2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides
Helene Dederer, Margaret Werr
Insect Biochemistry and Molecular Biology, Volume 41, Issue 1, Januar 2011

Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test
Jesper T. Andreasen, Elsebet Ø. Nielsen Jeppe, K. Christensen, Gunnar M. Olsen, Dan Peters, Naheed R. Mirza, John P. Redrobe
Journal of Psychopharmacology, 04/2010, DOI: 10.1177/0269881110364271

The Branched Photocycle of the Slow-Cycling Channelrhodopsin-2 Mutant C128T
Katja Stehfest , Eglof Ritter, André Berndt, Franz Barti and Peter Hegemann
Journal of Molecular Biology - Volume 398, Issue 5, 21 Mai 2010, Pages 690-702

Mechanisms underlying KCNQ1channel cell volume sensitivity
PhD thesis Sofia Hammami
Mai 2010

Intracellular Cysteine 346 Is Essentially Involved in Regulating Panx1 Channel Activity
Stefanie Bunse, Matthias Schmidt, Nora Prochnow, Georg Zoidl 1and Rolf Dermietzel,1,2
jbc, January 5, 2010

Ultrafast optogenetic control
Lisa A Gunaydin, Ofer Yizhar, Andre Berndt, Vikaas S Sohal, Karl Deisseroth & Peter Hegemann
Nature Neuroscience / January 2010

Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native /kr and Modulates Cardiac Action Potential Characteristics
Anders Peter Larsen, Soren-Peter Olesen
PLoS ONE / February 2010 / Volume 5 / Issue 2 / e9021

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system
Amyaouch Bradaiaa,b, Gerhard Trubec,Henri Stalderc,Roger D. Norcrossc, Laurence Ozmenc, Joseph G. Wettsteinc,Audrée Pinarda, Danièle Buchyc, Martin Gassmanna, Marius C. Hoenerc and Bernhard Bettlera,1
PNAS, September 29, 2009

Hemichannel-Mediated and pH-Based Feedback from Horizontal Cells to Cones in the Vertebrate Retina
Iris Fahrenfort, Marvin Steijart, Trijntje Sjoerdsma, Evan Vickers, Harris Ripps, Jorrit van Asselt, Duco Endemann, Jan Klooster, Robert Numan, Huub ten Eikelder, Henrique von Gersdorff, Maarten Kamermanns
PLos one / June 2009 / Volume 4 / Issue 6

Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by small changes in cell volume
Rikke Soe, Nanna MacAulay and Dan Klaerke
Neuroscience Letters / Volume 457 / Issue 2 / 26 Ju8ne / 2009 / Page 80-84

The Nicotinic Acetylcholine Receptors of the Parasitic Nematode Ascaris suum: Formation of Two Distinct Drug Targets by Varying the Relative Expression Levels of Two Subunits
Sally M. Williamson, Alan P. Robertson, Laurence Brown, Tracy Williams, Debra J. Woods, Richard J. Martin, David B. Satelle, Adrian J. Wolstenholme
PLos Pathogens / July 2009 / Volume 5 / Issue 7 / e1000517

a7 nicotininc acetylcholine receptor activation ameliorates scopolamine-induced behavioural chnages in a modified continous Y-maze task in nice
John P. Redrobe, Elsebet O. Nielsen, Jeppe K. Christensen, Dan Peters, Daniel B. Timmermann, Gunnar M. Olsen
European Journal of Pharmavology / 602 / 2009 / 58-65

Glu 87 of Channelrhodopsin-1 Causes pH-dependent Color Tuning and Fast Photocurrent Inactivation
Satoshi P. Tsunoda, Peter Hegeman
Photochemistry and Photobiology, Volume 85, Issue 2, pages 564–569, March/April 2009

The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials
Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, Dermietzel R.
FEBS J. 2009 276(21):6258-6270

Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I Kr current
Anders Peter Larsen, Soeren-Peter Olesen, Morten Grunnet and Thomas Jespersen
Pflügers Archiv of European journal of Physiology / Volume 456 / Number 6 / September 2008

Novel Acetylchloline and Carbamoylcholine Analogues: Development of a Funtionally Selective a4ß2 Nicotinic Acetylcholine Receptor Agonist
Camilla P. Hansen, Anders A. Jenson, Jeppe K. Christensen, Thomas Balle, Tommy Liljefors and Bente Frolund
Journal of Medical Chemistry / 2008 / 51 (23) ? pp 7380-7395

Channelrhodopsin-1 Initates Phototaxis and photophobic Responses in Chlamydomonas by Immediate Light-Induced Depolarization
Peter Berthold, Satoshi P. Tsunaoda, Oliver P. Ernst, Wolfgang Mages, Dietrich Gradmann and Peter Hegemann
The Plant Cell / Volume 20 / 1665-1677 / June 2008

Photoactivation of Channelrhodopsin
Oliver P. Ernst, Pedro A. Sanchez Murcia, Peter Daldrop, Satoshi P. Tsunoda, Suneel Kateriya and Peter Hegemann
The journal of Biological Chemistry / Volume 283 / NO 3 / pp. 1637-1643 / January 18 2008

The Roboocyte: Automated Electrophysiology Based on Xenopus Oocytes
Christine Leisgen, Mike Kuester and Christoph Methfessel
Methods in molecular biolgy: Patch-Clamp Methods and Protocols, page 87-111, 2007

Expression of ion channels in Xenopus oocytes. In: Clare JJ, Trezise, DJ (Eds) Expression and analysis of recombinant ion channels
Goldin AL
2006. Wiley-VCH, Weinheim, pp 1-25

Ion pore properties of ionotropic glutamate receptors are modulated by a transplanted potassium channel selectivity filter
Jutta Hoffmanna, Anna Gorodetskaiab and Michael Hollmann
Molecular and Cellular Neuroscience, Volume 33, Issue 3, 6 November 2006, Pages 335-343

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Dissertation: Der L-Typ Aminosäuretransporter 2 als möglicher kompensierender T3-Transporter bei Mct8-Defizienz: Untersuchung Slc7a8-defizienter Mäuse
Authors: Dipl. Biochem. Doreen Braun - Fachbereich Biologie, Chemie, Pharmazie der Freien Universität Berlin, 2012

Dissertation: Untersuchung des Mechanismus und der molekularen Bindestelle des Kv7.1/KCNE1-Inhibitors JNJ303
Authors: Eva Wrobel - Lehrstuhl für Biochemie I - Arbeitsgruppe Kationenkanäle - Bochum, Januar 2013

Dissertation: Charakterisierung von Pannexin1 in einem experimentellen Modell der Ischämie
Authors: Meike S. Rouxt - Dissertation Univ. Bochum, Fak. Biology, 02/2012

Oocytes in space
Authors: Dr. Stéphane Richard - ETH Zurich - Space Biology Group 2011

Dissertation: Molecular and functional characterization of communicating channels
Authors: Kathrin H. Engelhardt - Dissertation Univ. Bochum, Fak. Biology, 2011

PHD-Thesis: Optogenetic approaches to the study of hippocampal long‐term plasticity
Authors: Philipp Schönenberger Lawrence - Arbon, Schweiz - Basel, 2011





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